AB76. Adipose-derived stem cells improve erectile function through secretion of growth factor in aged rat

Transl Androl Urol, Vol 3, Suppl 1 September 2014 www.amepc.org/tau © Translational Andrology and Urology. All rights reserved. Pink1 KO rats acquired the functional disorder of detrusor over activity compared to wild type rats. Hyperplasia of smooth muscle and nerves were noted in the bladder wall of Pink1 KO rats. More specific nerve changes and specific causality among dopaminergic neuron loss, pathologic alterations of bladder, and functional changes should be investigated in the future. Pink1-/rat model of PD exhibited bladder dysfunction at the age of 40 weeks old. Detrusor over activity was the main change. Smooth muscle and nerves in bladder wall displayed the alteration of hyperplasia. This is a better transgenic rat model of PD induced detrusor over activity for future study.